Multiple cerebral aneurysms in lupus

Prasanna PV, Rajasekhar L, Varaprasad IR, Habibi S, Rakhee Kumar Paruchuri

Pdf Page Numbers :- 112-114

 Prasanna PV^1,*, Rajasekhar L², Varaprasad IR²_, Habibi S² and Rakhee Kumar Paruchuri³

¹Department of Rheumatology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India

²Department of Rheumatology, Nizams Institute of Medical Sciences, Hyderabad-500082, Telangana, India

³Department of Radiology, Nizams Institute of Medical Sciences, Hyderabad-500082, Telangana, India

*Corresponding author: Dr. P.V. Prasanna, Consultant Rheumatologist, Department of Rheumatology, Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India. Tel.: +91 9849145372; Email: prasanna.parimi.vijaya@gmail.com

Received 08 April 2016; Revised 05 June 2015; Accepted 20 June 2015; Published 28 June 2016

Citation: Prasanna PV, Rajasekhar L, Varaprasad I, Habibi S, Paruchuri RK. Multiple cerebral aneurysms in lupus. J Med Sci Res. 2016; 4(3):112-114. DOI: http://dx.doi.org/10.17727/JMSR.2016/4-027

Copyright: © 2016 Prasanna PV, et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

 Systemic lupus erythematosus (SLE) is an autoimmune chronic multisystemic inflammatory disease of unknown etiology. It has variable course and prognosis. Its clinical manifestations may be constitutional or specific to organ/system involved. Immunological aberrations are the cause for inflammation in various tissues. Nervous system involvement in SLE is common and has diverse clinical and morphological manifestations. Diagnosis of neuropsychiatric involvement remains difficult in SLE. Intracranial vasculitis is rare and results in cerebrovascular accidents (CVA). Young patients are at risk of CVA. Neuropathological features on biopsy include infarcts characterized by fibrinoid necrosis of small intracranial arterioles and capillaries. Fibrinoid necrosis, a common histological finding in SLE, may be responsible for aneurysmal formation. The increased risk and associated mechanisms of SAH in SLE is less well understood. The prevalence of SAH due to rupture of intracranial aneurysms is higher in SLE patients than in the general population, a phenomenon that is thought to be due to focal transmural lupus angitis causing rupture. SAH secondary to aneurysmal bleed is very rare and requires prompt immunosuppression for better outcome.

Keywords: subarachnoid hemorrhage (SLE); lupus; cerebral aneurysms; cerebral vasculitis; neuropsychiatric lupus